Neurological, skin, and circulatory issues can arise from deficiency of which nutrient?

• A. B6 deficiency
• B. Vitamin B2 deficiency
• C. Vitamin C deficiency
• D. Niacin deficiency

Answer: (A)

Vitamin B6 (pyridoxine) deficiency best fits this pattern because B6 serves as a critical cofactor in multiple pathways that affect nerves, skin, and blood health. It is essential for making neurotransmitters such as GABA, serotonin, and dopamine, so a shortage can lead to neurological symptoms like numbness, tingling, irritability, and cognitive changes. It also supports skin cell turnover and integrity, so deficiency can cause dermatitis, angular stomatitis, and glossitis. Additionally, B6 is involved in heme synthesis for red blood cells; without enough B6, anemia can develop, leading to circulatory symptoms such as fatigue and pallor. While other deficiencies can cause one or two of these issues, B6 most consistently links neurological problems, skin changes, and circulatory (anemia-related) symptoms together.